Tetracycline is not often used topically, but rather as an oral antibiotic. You can also use it as a solution or ointment at different strengths. Tetracycline contains sodium bisulfite, derived from sulfa. It can cause an allergic reaction and may cause yellowing of the skin. However, it's popular as an oral antibiotic with dermatologists. It may have the same side effects as the other two.
The best treatment for acne is preventative as well as pro-active. A good, regular cleansing routine will treat existing acne and prevent most outbreaks by keeping pores clear of dirt, grime and oils that clog them and cause acne infections. Astringents are also good cleansers but should be used with care. Because they dry up the oil on your face, you use them more sparingly than a good cleanser. If used too frequently, astringents can cause your skin to signal for more oil production and result in even oiler skin and more acne. One of the best astringents you can use is witch hazel. It's a natural plant-based substance and costs a fraction of commercially manufactured astringents.
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